HEART RATE REDUCTION IMPROVES BIVENTRICULAR FUNCTION AND INTERACTIONS IN EXPERIMENTAL PULMONARY HYPERTENSION
نویسندگان
چکیده
منابع مشابه
Balloon Pulmonary Angioplasty Improves Biventricular Functions and Pulmonary Flow in Chronic Thromboembolic Pulmonary Hypertension.
BACKGROUND It remains to be determined whether balloon pulmonary angioplasty (BPA) improves biventricular cardiac functions and pulmonary flow in patients with chronic thromboembolic pulmonary hypertension (CTEPH). METHODSANDRESULTS We enrolled 30 consecutive patients with inoperable CTEPH who underwent BPA, and carried out serial cardiac magnetic resonance imaging (CMR; M/F, 9/21; median age...
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Right heart failure in pulmonary arterial hypertension (PH) is associated with mechanical ventricular dyssynchrony, which leads to impaired right ventricular (RV) function and, by adverse diastolic interaction, to impaired left ventricular (LV) function as well. However, therapies aiming to restore synchrony by pacing are currently not available. In this proof-of-principle study, we determined ...
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AIMS The anti-anginal agent ivabradine slows heart rate (HR) by selectively inhibiting the I(f) current in the sinus node. We report an ex vivo study to evaluate the anti-ischaemic effect of ivabradine in terms of modulation of cardiac energy metabolism. METHODS AND RESULTS A Langendorff-perfused rabbit heart model was subjected to low-flow ischaemia and reperfusion. Cardiac metabolism was st...
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Background – Pulmonary arterial hypertension (PH) eventually leads to right heart failure. The use of β-blockers is strongly discouraged in PH, because of their acute negative inotropic and chronotropic e¡ ects. However, use of β-blockers in chronic (left) heart failure is safe and signi cantly reduces mortality. We investigated whether chronic low-dose treatment with bisoprolol (a cardioselect...
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BACKGROUND Pulmonary arterial hypertension (PAH) is a lethal disease characterized by obstructive pulmonary vascular remodeling and right ventricular (RV) dysfunction. Although RV function predicts outcomes in PAH, mechanisms of RV dysfunction are poorly understood, and RV-targeted therapies are lacking. We hypothesized that in PAH, abnormal microtubular structure in RV cardiomyocytes impairs R...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2017
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00493.2017